Protein Details: 5-hydroxytryptamine receptor 3A

Protein ID

ICDB_Pro_0505

Protein Name

5-hydroxytryptamine receptor 3A

Gene Name

Htr3a; 5ht3; Htr3

Organism

Rattus norvegicus (Rat)

Length

483 amino acids

AlphaFoldDB

AF-P35563-F1-model_v4.pdb

Function

Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes; which when activated cause fast; depolarizing responses in neurons.

Sequence

MPLCIPQVLLALFLSVLIAQGEGSRRRATQAHSTTQPALLRLSDHLLANYKKGVRPVRDWRKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPSIPYVYVHHQGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRTPEEVRSDKSIFINQGEWELLGVFTKFQEFSIETSNSYAEMKFYVVIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVQLVHKQDLQRPVPDWLRHLVLDRIAWLLCLGEQPMAHRPPATFQANKTDDCSAMGNHCSHVGSPQDLEKTSRSRDSPLPPPREASLAVRGLLQELSSIRHSLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in central and peripheral neurons

DOI ID

10.1097/00001756-199311180-00006; 10.1046/j.1471-4159.2000.0750240.x; 10.1523/jneurosci.22-15-06732.2002

RefSeq

NP_077370.2